Homologous recombination is the exchange of DNA strands of similar or identical nucleotide sequence. It can be used to direct error-free repair of double-strand DNA breaks and generates sequence ...

TROP2 expression in small bowel adenocarcinoma: A potential target for novel therapeutic strategies. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This ...

Analysis of tumor microenvironmental features of primary and synchronous liver metastases from patients with colorectal cancer using a deep learning algorithm. Real-world analysis of the impact of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Homologous recombination (HR) is important for ...

As primary spermatocytes of double knockout mice stop their differentiation in pachytene ... genes with known roles in meiosis, especially DNA synapse, homologous recombination and DNA repair, (2) ...

The investigation involved a comprehensive approach, including the generation of a Setd2-CD knockin mouse model through homologous recombination ... genes in both Setd2-CD and Setd2 knockout ...

Jan. 28, 2025 — A team of researchers has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA ...

While this shuffling, known as recombination, is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...