As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Ultimately, this can lead to liver cirrhosis and hepatocellular carcinoma. The intricate role of hepatic macrophages, particularly Kupffer cells (KCs) and monocyte-derived macrophages (MoMFs), in the ...

Hepatic macrophages are a remarkably heterogeneous population consisting of self-renewing tissue-resident phagocytes, termed Kupffer cells (KCs), and recruited macrophages derived from peritoneal ...

Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The study reveals TREM2's role in clearing damaged cells and promoting recovery ...

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific ...

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific ...

Liver injury in Trem-2-/-mice is associated with elevated levels of reactive oxygen species and lipid peroxidation. In line with TREM-2 effects on inflammation and injury, Kupffer cells and hepatic ...

MerTK-deficient mice exhibit persistent liver injury and inflammation after APAP overdose and are characterised by a depletion in MHCII high-bearing prorestorative resident Kupffer cells and by ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Feb. 6, 2025 — A recent study investigates how polyester microdroplets, potential precursors to modern cells, could form under realistic early Earth conditions. Researchers pushed these ...