Mipomersen acts through neutralization of Aporef-100 mRNA and reduces hepatic VLDL secretion, resulting in a reduction in the plasma levels of all ApoB-containing ... of LDL receptor via direct ...

bnHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland boSchool of Public Health, Tongji Medical ...

Data from the Framingham Heart Study (FHS) participants demonstrate a significant increase in apoB levels (p < 0.0001 for trend) and LDL particle concentration as assessed by the NMR method (p < 0 ...

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the details of how LDL interacts with its receptor have remained elusive. The defining protein of LDL is a single copy of apolipoprotein B-100 (apoB-100), one of the largest translated proteins in ...