Mipomersen acts through neutralization of Aporef-100 mRNA and reduces hepatic VLDL secretion, resulting in a reduction in the plasma levels of all ApoB-containing ... of LDL receptor via direct ...

Data from the Framingham Heart Study (FHS) participants demonstrate a significant increase in apoB levels (p < 0.0001 for trend) and LDL particle concentration as assessed by the NMR method (p < 0 ...

These value shares consistently pop up in UK investor’s portfolios. For beginners eyeing long-term growth, they make a compelling case. When investing, your capital is at risk. The value of your ...

the details of how LDL interacts with its receptor have remained elusive. The defining protein of LDL is a single copy of apolipoprotein B-100 (apoB-100), one of the largest translated proteins in ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

LDL-C reduction was 45.3% at Month 6 and 29.2% at Month 48 in those cases who remained on lomitapide. At any time after initiating treatment, 65.4% patients achieved LDL-C <100 mg/dL and 41.1% ...

aMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain. bUniversidad de Córdoba, Córdoba, Spain. cReina Sofia University Hospital, Córdoba, Spain. dCIBER Fisiopatología de ...