In this Research Topic, we aim to explore either of the following themes: 1. Key Immune Components in the Tumor Microenvironment 1.1. Tumor-Associated Macrophages (TAMs): TAMs (M1) are often polarized ...

Surrounding these epithelial cells is a microenvironment of supporting ... effects on lymphocytes and indirectly by tuning tumor-associated macrophages function.

Background: Macrophages play a dual role in the tumor microenvironment(TME), capable of secreting pro-inflammatory factors to combat tumors while also promoting tumor growth through angiogenesis and ...

The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, established to support high-risk, high-reward ideas with the potential to ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

Explore how immune time-resolved Förster resonance energy transfer (iFRET) offers new insights into predicting immunotherapy ...

Finding ways to tackle tumour associated macrophages, part of the “tumour microenvironment” that ... This will involve moving its first cancer drug into clinical trials, and starting work ...

Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face. Locally ...

Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours might restore their antitumourigenic properties and provide a precise strategy for anticancer therapy.

Talimogene laherparepvec (T-VEC) demonstrates efficacy in cutaneous BCC, enhancing resectability and altering immune cell ...