Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...

Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small ...

Microglia, the major CNS-resident macrophages, are crucial for the immune response of the CNS against infection and injury, as well as for brain development and function. However, the current ...

Microglia can engage in phagocytosis, and are involved in immune responses within, as well as the development and remodelling of the nervous system. Their shape varies depending on the ...

Ncardia’s iPSC-derived microglia may aid ALS research and help to screen new therapies that target inflammation in ALS.

The FDA has granted Fast Track Designation to Lundbeck’s investigational drug, amlenetug, a potential new treatment option targeting Multiple System Atrophy (MSA). Lundbeck has recently initiated ...

Inflammation is triggered by the immune system and is part of the body's natural response to injuries or disease. However, abnormal inflammation has recently been established as a hallmark for ...

Intriguingly, recent studies have shown that both microglia and BAMs originate from the same myeloid progenitor during yolk sac hematopoiesis, but their developmental fates diverge within the brain.

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

Microglia are imperative to maintaining neuronal function by clearing toxins in the brain and central nervous system. But if they are overactive, they can damage neurons instead and, in some cases, ...