Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be activated by various dietary ...

Edited by: Stephen P. Hoffert S.A. Kliewer, J.M. Lenhard, T.M. Willson, I. Patel, D.C. Morris, J.M. Lehmann, "A prostaglandin J2 metabolite binds peroxisome ...

School of Pharmacy, The University of Queensland, Brisbane 4102, Australia Inflammatory Bowel Diseases Group, Mater Research Institute─UQ at Translational Research Institute, The University of ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Objective Nuclear receptors are known to regulate both immune and barrier functions in the GI tract. The nuclear orphan receptor NR2F6 has been shown to suppress the expression of proinflammatory ...

Research has shown that ICA downregulates peroxisome proliferator-activated receptor gamma (PPARγ) expression, promoting osteogenic differentiation and inhibiting adipogenic differentiation in ...

Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their ...

Coffee is one of the most popular beverages in the world. Several studies consistently show that coffee drinkers with chronic liver disease have a reduced risk of cirrhosis and a lower incidence ...

In this study, we aimed to understand the role of MTCH2 in metabolism. While MTCH2 is well-known for its role in apoptosis as the mitochondrial receptor for the pro-apoptotic protein BID (Zaltsman et ...