ASFV作为核质大DNA病毒，类似于牛痘病毒，自身可以编码与真核生物同源的RNAP核心亚基与转录因子，而不依赖宿主细胞完成转录过程。RNAP复合体作为 ...

研究结果表明，在某些情况下，负责将DNA复制成RNA的RNA聚合酶（RNAP）可以产生猖獗的r -环——如果没有一种叫做RapA的蛋白质的干预的话。 “r环通常是坏消息，所以细胞有许多多余的机制来阻止它们的形成，”分子生物物理实验室的负责人Seth Darst说。“我们 ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP) enzyme responsible for copying DNA into RNA can generate rampant R-loops -- if not for the intervention of a ...

Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks ...

The jaws of life All living things rely on RNAP to transcribe DNA into RNA. In bacteria, researchers have long known that transcription begins when RNAP clamps onto a DNA strand and initiates the ...