What was of particular interest (in relation to the recovery of John Famechon) was the process of discovering what was ...

The axon initial segment (AIS) is where nerve signals begin, and its adaptability is key to brain function. Scientists have found that the AIS changes in response to activity levels, helping neurons ...

NanoScience Technology Center, University of Central Florida, Orlando, Florida 32826, United States Department of Materials Science and Engineering, University of Central Florida, Orlando, Florida ...

Motivated by these findings, we developed network simulations incorporating a bi-phasic structural plasticity rule governing activity-dependent synapse formation. We showed that this biphasic rule ...

we implemented a structural plasticity rule inspired by ref. (Holt-maat and Svoboda, 2009) where each synapse whose efficacy falls below a fixed threshold 𝑊thr is pruned from the dendrite. This work ...

Synapse Organization in Health and Disease Synapse size and strength is tightly ... Excitingly, we now also study Crimpy’s mouse ortholog, called Crim1, in mammalian motorneuron development, together ...

Alterations of synaptic plasticity are observed in several neurodegenerative disorders ... In this respect, LTP and LTD can serve as synapse survival and death signals, respectively. Thus, conditions ...

The loss of Ube3A during normal aging may lead to rigid synapses similar to Ube3A KO mice that lack synaptic plasticity (Yashiro et al., 2009). A richer picture of the aging synapse is emerging from ...