These findings suggest that the presence of JAK2 mutations may complicate the clinical picture of CML, leading to misinterpretations of disease progression or treatment resistance[4]. Moreover ...

Genetic mutations should be considered when selecting the optimal treatment for relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), according to a recent network meta-analysis published in ...

The treatment landscape of myelofibrosis has undergone a significant ... regulates the transportation of transcription factors to the cell nucleus. However, in myelofibrosis, JAK2-STAT signaling is ...

Genetic mutations in a breast tumor can inform treatment decisions in metastatic breast cancer. Genetic testing may be a good idea at diagnosis and progression of metastatic breast cancer. Genetic ...

1,2 This article describes the etiology, diagnosis, and treatment of primary myelofibrosis ... 7,13 It’s an inhibitor of the JAK2 enzyme. As a consequence of JAK2 inhibition, ruxolitinib ...

In an interview, Andrew Kuykendall, MD, discussed fedratinib’s potential as an effective option for patients with ...

If they have a JAK2 [mutation], it can cause clots in the mesenteric vein or in the portal system ... Anusha Madadi, MD: I use the NCCN criteria; splenomegaly, fatigue, pruritus, or worsening ...

A heterozygous mutation in the PTPN2 gene has recently been described in several patients exhibiting ... Limited clinical data is available advocating the use of jak-inhibitors as an effective ...

Lecia Sequist discusses the future of treatment for EGFR-positive lung cancer. Dr. Lecia Sequist discussed the treatment options for EGFR-positive lung cancer. Dr. Lecia Sequist discusses the ...

A hot topic in life science today is the question of what causes aging. Is it damage caused by gene mutation or by gene expression? Trey Ideker, a professor of health sciences at UC San Diego ...