Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

A study published by the Journal of Traditional and Complementary Medicine and e-published by the U.S. National Library of ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

A Memorandum of Understanding (MOU) was officially signed today at the Courts Belmopan store to launch a comprehensive road safety initiative. The collaboration aims to raise awareness among both ...

Western blot analysis was performed to examine the components of the PI3K/AKT signaling pathway. Results: Among the sixty-four shared targets identified, JUN and CCND1 were the most frequently ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

产品活性：Capivasertib (AZD5363) 是一种口服有效的 pan-AKT 激酶抑制剂，抑制 Akt1，Akt2 和 Akt3，IC50 分别为 3，7 和 7 nM。 体外：Capivasertib 是一种新型吡咯并嘧啶衍生化合物，可抑制所有 AKT 亚型，效力为 10 nM 或更低。Capivasertib 可抑制这些底物的磷酸化，在 3 种细胞系 ...