Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...

Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States ...

Biopharmaceutical and Regenerative Sciences, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan ...

Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, United States Department of Psychiatry, Weill Institute for Neuroscience, University ...

Amyloidosis develops from a bone marrow disorder. It occurs when an abnormal protein, called amyloid, builds up and forms deposits in the body. Amyloidosis is closely linked to MM. Amyloid light ...

This valuable study presents a series of results aimed at uncovering the involvement of the endosomal sorting protein SNX4 in neurotransmitter release. While the evidence supporting the conclusions is ...

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid precursor protein (APP) and tau, ...

2008), as well as on amyloid precursor protein (APP) processing and Aβ production (Sutinen et al ... Differentiated proteins within the gels were stained with PlusOne™ Silver Staining Kit (GE ...