Finally, in vivo animal studies confirmed that HDCA inhibited CRC proliferation without hepatotoxicity. Conclusion: Our findings indicate that HDCA suppresses the EREG/EGFR signaling route by ...

The APOE region or locus is a segment of DNA with several genes in close apposition, including APOE. Its boundaries are not strictly defined, spanning a stretch between 0.2 and 10 Mb long. In 5’ to 3’ ...

1 Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany 2 DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, ...

Figure. Matrix metalloproteinase (MMP) activation plays a central role in arterial proinflammatory remodeling and stiffening, which is a structural and functional signature of aging, hypertension, and ...

Seven-week-old male C57BL/6 (wild-type) mice (Oriental Yeast, Tokyo, Japan) or TLR2-deficient mice consumed a standard diet (CLEA Japan, Tokyo, Japan). Food and water were provided ad libitum. Human ...