In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative ...

In summary, MTCH2 deletion disrupts energy metabolism and redox cofactor pathways, resulting in inadequate expression of transcription factors essential for adipocyte differentiation. In this study, ...

Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States Institute for Drug and Biotherapeutic Innovation, Saint Louis University, Saint Louis, Missouri 63103, ...

2017). Moreover, BM-MSCs isolated from diabetic patients exhibit decreased paracrine secretion and a greater proclivity to develop into adipocytes (Ferland-McCollough et al., 2018). Donor-related ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China ...

Nonetheless, the limited expression of β3-AR in human adipocytes restricts its clinical application. The objective of this study was to identify a GPCR that is highly expressed in human adipocytes and ...

Department of Biomedical Sciences, Faculty of Health Sciences (L.W., J.L., P.T., D.Z., L.T., Y.W., L.D.), University of Macau, China. The Ministry of Education ...

CBL-514, a potentially first-in-class small-molecule drug, is an injection lipolysis drug that can induce adipocyte apoptosis and lipolysis to reduce subcutaneous adiposity in treatment areas in ...