These patterns are the basis of a primitive immune system that bacteria use to ‘remember’ the DNA of viral invaders by incorporating the DNA sequence of the virus within the CRISPR patterns. The Cas9 ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Innovative synthetic biology techniques are revolutionizing microbiota-based therapies, enhancing microbial functions for ...

With vasa-Cas9, high efficiency and self-limiting suppression was achieved. Applying the CRISPR-Cas9 system to edit high GC content genomes has been challenging due to its high off-target activity.

"People have known for a while that Cas9 causes an immune response ... do its job," added Friedrich. Many CRISPR-based therapies use nucleases derived from bacteria. About 80% of people have ...

Simultaneous discoveries in art and science highlight humanity's shared creativity, problem-solving, and the ...

"This type of gene editing should also allow for the treatment of diseases whose origin is not genetic or whose origin cannot ...

It feels fantastic,” said Blau, who thanked her lab members and colleagues for their support and dedication. “This ...

July 22, 2024 — The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for ...