Additional funding from new investor Korys, joining existing syndicate members Novo Holdings and Bioqube Ventures, brings total seed financing to €21.5mFunds will be used to further develop ...

Commit Biologics ("Commit"), a pioneer in the activation of the complement system to treat cancer and autoimmune disease, today announces a ?5.5m extension to its seed financing. The contribution from ...

Statistical tests were performed as described in the figure legends. CD28 is a co-stimulatory molecule best known for its role in T cell activation. In LLPC, CD28 has been suggested to contribute to ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

Importantly, inhibition of MASP-2 has been demonstrated to leave intact the antibody-dependent classical complement activation pathway, which is a critical component of the acquired immune ...

To answer this question, the authors used a combination of in vivo and ex vivo experiments in mice to demonstrate ligand-independent activation of Notch1 by circulation induced-mechanical stress and ...

The processed N-terminal T-Mac half binds to the chemokine receptors FPR1 and CXCR1/2 to block chemotaxis and activation of neutrophils. The T-Mac C-terminal fragment is a cysteine protease that ...

Findings suggest that the complement system plays a role in the onset of acute kidney injury in critically ill patients. Urinary Ba, a fragment of complement factor B, may be a biomarker and ...

Furthermore, smooth muscle cell–specific Abro1-knockout mice and Brcc3-knockout mice showed attenuated HFHSD-induced arterial stiffness and activation of transforming growth factor-β–Smad signaling.