All the knockout ES-cell lines would be archived and freely distributed to the research community. A portion of the ES-cell lines would be used to create live mice through germline transmission ...

These gene expression changes became more robust over time and mirrored those of the Mecp2 germline knockout mice. "These data revealed a molecular cascade that drives disease independent of any d ...

To understand the relevance of this 'gut-germline' axis to traits inherited by offspring, the scientists mated either untreated or dysbiotic males with untreated females. Mouse pups sired by ...