gene knockout and knock-in studies are typically performed on cancer cell lines to investigate the efficacy of an existing ...

To achieve their research goals, the lab employs a variety of experimental approaches, including in vivo models such as orthotopic xenograft models and patient-derived xenografts, as well as in vitro ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

Cellular and in vitro biochemical experiments showed ... By constructing a mouse model with a complete knockout of the Martre gene family, the researchers observed delays in early embryonic ...