This approach highlights the importance of understanding the mechanisms that regulate mast cell survival and function, particularly the role of the KIT receptor and its ligand, stem cell factor (SCF).

Mast cells can recycle the material from the neutrophils to boost their function and metabolism. In addition, mast cells can release the newly acquired neutrophil components in a delayed manner ...

One significant area of research has been the role of the CD300 receptor family in regulating mast cell function and immune responses. For instance, a study demonstrated that the inhibitory ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

they hope to engineer new GluK2-activating compounds that could eventually be tested in clinical trials. They have also applied for a patent for the use of SYM2081 to suppress mast cell function.

The ketogenic diet has proven to be useful in mast cell tumors, but many other types of cancer need to be investigated. In ...

In turn, substance P activates mast cells, which are key coordinators of inflammation that drive itchiness and inflammation via recruitment of neutrophils. “In contact dermatitis, mast cells are ...

The same mechanisms involved in COVID-related cardiovascular events are responsible for COVID-related myocarditis.

Numbers of mast cells, eosinophils and intraepithelial lymphocytes were assessed by immunohistochemistry ... We suggest that impaired intestinal barrier function is a pathophysiological mechanism in ...

However, as the authors acknowledged, “Whether CS components can bind MR1, impact MAIT cell functions in the lungs, and how they are related to the pathogenesis of COPD are yet to be elucidated.” ...

Scratching an itch is almost irresistible — even though it can make a problem worse. Now researchers have discovered a mechanism that explains the "itch-scratch cycle".