TABLE 1. Signal Pathways Mediating Effects of Mechanical Stress Stimulation on Osteoblast like cells. FSS, fluid shear stress; OPG: osteoprotegerin; DKK, Dickkopf-related protein; RUNX2, Runt-related ...

Similar to miR-23a, miR-137-3p targets Runx2 and CXCL12, and its silencing can promote bone formation and angiogenesis, thus preventing osteonecrosis. MiR-23a is an important member of the ...

This study presents important findings demonstrating that FZD5 and FZD8, two of the ten Frizzled proteins, undergo Wnt-mediated endocytosis. The E3 ubiquitin ligases RNF43/ZNRF3 regulate their ...

Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We ...

Correspondence to Professor Daozhang Cai and Dr Xiaochun Bai, Department of Orthopedics, Academy of Orthopedics - Guangdong Province, Orthopedic Hospital of Guangdong Province, The Third Affiliated ...

The mRNA expression levels of genes associated with hypertrophy (MMP13, ADAMTS-5, COLX and Runx2) by human chondrocytes transfected with CA-Rac1, DN-Rac1 or GFP were assessed with real-time PCR. Total ...

Osteogenic blockade may be due to an increase in expression of the Wnt antagonist DKK1. Interestingly, osteocommitment was also induced by serum obtained from patients with AS, which was also ...