eLife1 个月
CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility
Moreover, CCDC113 was identified as a structural component of HTCA, collaborating with SUN5 and CENTLEIN to connect sperm head to tail during spermiogenesis. Together, our studies reveal that CCDC113 ...
eLife1 个月
CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility
In this paper, Wu et al. investigated the physiological roles of CCDC113 in sperm flagellum and HTCA stabilization by using CRISPR/Cas knockouts mouse models, co-IP and single sperm imaging. They find ...