2025年1月22日 · The apolipoprotein E (APOE) gene, located on chromosome 19, remains the primary genetic factor associated with late-onset Alzheimer's disease. 1 In European populations, the ε4 haplotype of APOE, present in approximately 14% of individuals, significantly increases Alzheimer's disease risk, while the less common ε2 haplotype (∼8%) appears to confer a protective effect. 2 Despite its ...

Apolipoprotein E (apoE)1 is an apoprotein found in chylomicrons, chlyomicron remnants, very low density lipoproteins, and high density lipoproteins in man and in other mammalian species. The complete amino acid sequence of apoE was reported by Rail et al. (1982).

Localization of ApoE Structural Gene By Somatic Cell Hybrids. Mapping of the apoE structural gene on human chromosomes was per­ formed by Southern blot analysis of DNAs isolated from a panel of

Apolipoprotein E gene mapping and expression: localization of the structural gene to human chromosome 19 and expression of ApoE mRNA in lipoprotein- and non-lipoprotein-producing tissues. Yen Chiu Lin-Lee, Fa Ten Kao, Peter Cheung, and ; Lawrence Chan

1985年7月2日 · Apolipoprotein E (apoE) binds to specific cell-surface receptors and appears to be an important determinant in lipoprotein metabolism in man. Cloned human apoE cDNA (pAE155) was used as a probe in chromosome mapping studies to detect the structural gene sequences in human--Chinese hamster cell hybri …

The apolipoprotein E (APOE) gene on chromosome 19q13.32, was the first, and remains the strongest, genetic risk factor for Alzheimer’s disease (AD). Additional signals associated with AD have been located in chromosome 19, including ABCA7 (19p13.3) ...

Expression of the human APOE gene results in a 317-amino-acid-long APOE precursor protein, from which the mature APOE protein with a length of 299 amino acids is formed after cleavage of an N-terminal 18-amino-acid-long signal peptide .

2025年1月4日 · The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes.

The gene itself is located on chromosome 19:q13.3, together with the apoC genes APOC1, APOC2, and APOC4, which are members of the exchangeable lipoprotein family, and in proximity to the mitochondrial translocase of the outer membrane gene (TOMM40). This is another locus involved in the development of AD [11, 12, 13, 14, 15].

This study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable...