2020年8月27日 · Here we show that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in human and mouse. At the initiation of tracheal development, …

Studies with transgenic mice based on the Tbx4 lung enhancer showed that angiogenic vessels trigger lung mesenchymal stem cell differentiation and commitment to endothelial progenitor …

Although most TBX4 data are derived from studies in mice, analyses of human cells have shown highly specific TBX4 expression in pulmonary fibroblasts, likely regulated by lung-specific …

2024年9月18日 · Currently, the effect of TBX4 loss-of-function on later stages of lung development and predisposition to lung disease, including PH, is not well understood. …

2024年9月18日 · Currently, the effect of TBX4 loss-of-function on later stages of lung development and predisposition to lung disease, including PH, is not well understood. …

2016年8月1日 · Mice with both TBX4 and TBX5 deficiency exhibit severely reduced lung branching at mid-gestation, indicating that TBX4 is important in regulating the proliferation, …

While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remain to be elucidated. We have used a combination of …

2022年10月1日 · The TBX4 gene encodes a member of TBX family of proteins, containing a T-box DNA-binding domain, and is a transcription factor essential for lung development. [15] A …

2008年8月1日 · Our transgenic and comparative studies show that two different cis- regulatory elements contribute to hindlimb expression. Targeted knockout of one of these elements …

2021年9月24日 · This study concludes that species sensitive to thalidomide produce Crbn-dependent teratogenic phenotypes and the resultant effect cannot be simply explained by a …