Viral receptors are key regulators of host range, tissue tropism, and viral pathogenesis. Many viruses utilize common viral receptors including sialic acid, cell adhesion molecules such as immunoglobulin superfamily members and integrins, and phosphatidylserine receptors.

2024年2月20日 · We identify cellular proteins that are preferentially used as virus receptors, which tend to be plasma membrane proteins with a high propensity to interact with other proteins. Using machine learning, we assign cell surface proteins a score that predicts their ability to function as virus receptors.

Virus entry pathways are largely defined by the interactions between virus particles and their receptors at the cell surface. These interactions determine the mechanisms of virus attachment, uptake, intracellular trafficking, and, ultimately, penetration to the cytosol.

A classical definition of a virus receptor would be the cell-surface molecule that mediates virus attachment and cell entry. Our current understanding of these processes demonstrates that many viruses use different molecules to mediate attachment and post-attachment entry events.

Virus receptors refer to host cell membrane components that can specifically bind to viruses, mediate virus invasion, and promote virus infection. Their chemical essence is glycoproteins, proteoglycans, lipids, or glycolipids, most of which belong to proteins.

Inhibitors of virus entry can prevent virus attachment, or bind to entry intermediates; small organic molecules, peptides, soluble receptors and antibodies are in clinical trials.

The most commonly used definition of a viral receptor is a plasma membrane constituent that binds to an incoming virus in a specific manner and enables subsequent cell entry steps that ultimately lead to productive infection, i.e., production of progeny virus.

This review emphasizes the virus-receptor interactions of human immunodeficiency virus, the rhinoviruses, the herpesviruses, and the coronaviruses. These interactions are often found to be complex and dynamic, involving multiple sites or factors on both the virus and the host cell.

2024年1月30日 · This table lists virus receptors published and having a valid role in vivo. The receptors function have been classified as adhesion or entry receptors. The Type indicates the general class of molecule bound by the virus: transporter, polysaccharide, lectin,..

2020年6月3日 · These findings reveal a mechanism of virus entry in which receptor engagement and signal transduction bring the coreceptor to viral particles at the cell surface, and could form the basis...