The Nile Rat gets Metabolic Syndrome that develops into diet-induced Type 2 Diabetes that is similar to human T2DM: insulin resistance, hyperinsulinemia, increased body fat, hypertension, elevated Triglycerides with decreased High-Density Lipoproteins, and eventually hyperglycemia and beta cell failure resulting in depressed insulin and end ...

2013年3月20日 · As its common name suggests, the Nile grass rat is native to the grasslands of sub-Saharan Africa and the southern Arabian Peninsula 1. This small, stocky rodent has a generally rounded...

The Nile rat, also known as the African grass rat (Arvicanthis niloticus), and the Sand rat (Psammomys obesus), are North African rodents that appear to be the only two naturally, well documented, presumably polygenic models of diabetes displaying nutritional attributes that mimic the spontaneous pathophysiology of MetS and T2DM in humans, i.e ...

The range of African grass rats, Arvicanthis niloticus, is traditionally held to extend along the Nile river valley and across most of sub-Saharan Africa, with the exception of the southern and southwestern regions of the continent.

2022年11月8日 · The Nile rat (Fig. 1a), also known as the Nile grass rat or African grass rat, is a promising diurnal model organism to address the translational gap between animal research and human biology, particularly in two areas—circadian rhythms and type 2 diabetes.

In the present article, I summarize some of the features of the Nile grass rat that make this species an attractive laboratory animal. The Nile grass rat, sometimes also called unstriped...

The African grass or Nile rat (NR) (Arvicanthis niloticus) is a herbivorous diurnal rodent which is used as a biological model for research on type 2 diabetes mellitus (T2DM) and the circadian rhythm. Similar to humans, male NRs develop T2DM with high-carbohydrate diets.

2018年2月18日 · Accordingly, the Nile rat provides a unique opportunity to identify the nutritional factors and underlying genetic and molecular mechanisms that characterize human T2DM. Keywords: Nile rat; animal models; glycemic load; metabolic syndrome; nutrition; type 2 diabetes.

2009年12月14日 · Here, we introduce the Nile grass rat (NGR), Arvicanthis niloticus, as a novel model of MetS. Studies of over 1100 NGRs in captivity, fed normal chow, revealed that most of these animals spontaneously develop dyslipidemia …

2023年12月15日 · The African grass or Nile rat (NR) (Arvicanthis niloticus) is a herbivorous diurnal rodent which is used as a biological model for research on type 2 diabetes mellitus (T2DM) and the circadian rhythm. Similar to humans, male …