Abstract 1807: T cell conditional knockout mouse model of the ...
2021年7月1日 · This study revealed that targeting BCATm in T cells may offer an advantage in mice to better fight lymphoma cancer and represents an attractive target for future …
Dysfunction of exhausted T cells is enforced by MCT11-mediated …
2024年11月8日 · Given the effects of conditional knockout of MCT11 in T cells, we treated tumor-bearing mice with MCT11-blocking monoclonal antibodies and found that the blockade of …
Conditional Knockout Mice Reveal Distinct Functions for the …
T cells lacking CBP or p300 had reduced tumor necrosis factor alpha gene expression in response to phorbol ester and ionophore, while signal-responsive gene expression in CBP- or …
Notch1 and T-cell development: insights from conditional knockout …
2001年3月1日 · However, use of the Cre-loxP targeting strategy has allowed the development of conditional knockout mice in which Notch1 can be specifically inactivated either in BM …
SATB1 prevents immune cell infiltration by regulating chromatin ...
2024年10月11日 · In this study, we showed that the conditional knockout of Satb1 in CD4 + T cells (Satb1 cKO) resulted in T cell hyperactivation and inflammatory cell infiltration, indicative …
Tox4 regulates transcriptional elongation and reinitiation during ...
2023年6月7日 · Here we show that Tox4 conditional knockout in mice reduces thymic cellularity, partially blocks T cell development, and decreases ratio of CD8 to CD4 through decreasing …
Conditional Knockout Mice Reveal an Essential Role of Protein ...
To investigate the in vivo roles of PP4 in T cells, we generated conventional and T-cell-specific PP4 conditional knockout mice. We found that the ablation of PP4 led to the embryonic …
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T ...
2025年1月22日 · Chimeric antigen receptor (CAR)–T cells have demonstrated remarkable efficacy in treating relapsed and refractory B cell malignancies, leading to durable complete …
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
2023年1月25日 · Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here, we show that T cell–specific RIPK1 deficiency in mice leads to the …
Contrasting cytotoxic and regulatory T cell responses underlying ...
Guo et al. trace immune cell dynamics in patients with hepatocellular carcinoma (HCC) receiving neoadjuvant anti-PD-1 plus lenvatinib by single-cell multi-omics technologies. Compared with …