2023年4月12日 · APOE4 is associated with insulin resistance in the brain. In a comprehensive review of dementia prevention strategies, a low-carbohydrate diet or a low-glycemic index diet is recommended for people with the APOE4 variant .

The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 provides a tool for the ...

For Apoe4 carriers, diet should be a top priority in your fight against Alzheimer’s. Apoe4 carriers and non-carriers metabolize food differently. It is important to understand how we respond to fat and other macronutrients so that we can optimize our diets in order to reduce our risks of Alzheimer’s disease.

2024年8月28日 · Based on current evidence, the best way to lower risk is with a Mediterranean diet. This eating pattern likely provides nutrients that work together to decrease risk. The effects may even be exaggerated in APOE4 carriers. A ketogenic diet may help lessen symptoms for those who already have mild-to-moderate Alzheimer’s.

2024年10月16日 · Dr. Dale Bredesen has created the ReCODE protocol that involves multiple strategies to address specific health issues that contribute to Alzheimer's Disease (AD).

2020年6月9日 · To understand the interactions of APOE isoforms and diet, we analyze how cellular trafficking of apoE proteins affects energy metabolism, the immune system, and reproduction. The age-accelerating APOE4 allele alters the endosomal trafficking of cell surface receptors that mediate lipid and glucose metabolism.

APOE4: The Heart of a Brain-Protective Diet. Given the increased risk of cognitive decline and Alzheimer's disease associated with the APOE4 variant, individuals with this genotype may consider a diet rich in brain-boosting nutrients.

2021年4月19日 · The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 provides a tool for the potential prevention of disease.

2025年1月19日 · A common diet recommended for ApoE ε4s is the Mediterranean diet because it is high in monounsaturated fats. Another commonly recommended diet is a high fat diet Ketosis_and_Ketogenic_Diet . We know to stay away from unhealthy fats, and saturated fats are said to be ill-advised for ApoE ε4s, but which fats truly are unhealthy?

2022年7月21日 · Dr Gundry has been regularly testing and tweaking the diet and supplementation regimen of his patients since 2002. This testing includes the ApoE4 allele. He has followed thousands of ApoE4 patients. He has specific dietary recommendation for carriers of the ApoE4 allele, which is discussed further in this post.