The brain amyloid of Alzheimer disease (AD) may potentially be imaged in patients with AD by using neuroimaging technology and a radiolabeled form of the 40-residue beta-amyloid …

Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's …

1995年10月24日 · Binding of the 125I,bio-A beta 1-40/SA-OX26 conjugate to the amyloid of AD brain was completely inhibited by high concentrations of unlabeled A beta 1-40. In conclusion, …

2023年8月28日 · Amyloid beta peptide is a 42-amino acid peptide and derives from the precursor protein, amyloid beta precursor protein (APP). The amyloid beta precursor protein is a …

The 3 major features of AD within the neuronal system. a Cleavage of APP, and formation and accumulation of extraneuronal Aβ.b Formation and deposition of intraneuronal NFTs.c …

In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and …

The neuropeptide beta amyloid (Aβ) is present in the brain throughout life, but accumulates with age, with levels rising dramatically years prior to the diagnosis of Alzheimer's disease (AD) …

2024年12月1日 · In our current work, we investigated the hypothesis that A β 42 exposure drives an increase in vascular cell adhesion molecule-1 (VCAM-1) expression, a cerebrovascular …

Amyloid-beta (Abeta) is cleared from the brain by both proteolytic digestion and transport across the blood-brain-barrier into the peripheral circulatory system. To investigate the role peripheral …

2025年1月16日 · Determinants of amyloid-beta metabolism in age-related neurocardiovascular diseases. Increased amyloid-beta blood levels, triggered by the presence of specific genetic …