Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of amyloid beta (Aβ) protein that present mainly in the grey matter of the brain. [1][2][3][4] Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques.

2016年3月31日 · JACKSONVILLE, Fla. — Mayo Clinic researchers led a laboratory study that found a new way to prevent the accumulation of amyloid plaque – a key feature of Alzheimer’s disease – by eliminating a class of molecules called heparan sulfates that form on brain cells.

2023年5月13日 · Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a protein called amyloid builds up in organs. This amyloid buildup can make the organs not work properly. Organs that may be affected include the heart, kidneys, liver, …

2023年1月2日 · Amyloid plaques are aggregates of misfolded proteins that form in the spaces between nerve cells. These abnormally configured proteins are thought to play a central role in Alzheimer's disease.

Amyloid plaques (also called neuritic or senile plaques) are formed by abnormal proteolytic cleavage of amyloid precursor protein (APP), a membrane protein produced in the endoplasmic reticulum and transported to the Golgi complex for cleavage by any of three secretases: α, β, or γ.

2024年2月22日 · Amyloid plaques (orange) deposited in between brain cells responsible for communication (blue) and immune response (red). Amyloids are protein fragments produced from the amyloid precursor protein (APP) that can group together and form clumps in various organs and tissues, including the liver, kidneys, and brain.