A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, …
2024年10月30日 · The ApoE aggregates even managed to seed plaques in ApoE knockout 5xFAD mice, which typically have few plaques. Human ApoE had the same plaque-seeding …
APOE Knock-out - ALZFORUM
Inactivation of the endogenous mouse APOE by homologous recombination and insertion of a neomycin cassette. Other Phenotypes. ApoE is undetectable in the plasma of these …
APOE4 Knock-In (JAX) - ALZFORUM
2018年11月30日 · APOE4 knock-in mice express a humanized APOE4 allele from the endogenous ApoE locus. APOE was humanized by replacing mouse ApoE exons 2, 3, and …
ApoE Binds Complement Protein, Keeps Inflammatory Cascade in …
2019年2月11日 · Using ApoE-knockout and humanized ApoE3- and ApoE4-knock-in mouse models, they examined physiological and immunological changes in the choroid plexus. They …
Do Lipids Lubricate ApoE's Part in Alzheimer Mechanisms?
Not everyone reported such a stark difference between APOE isoforms, however. Gilbert di Paolo's group at Denali Therapeutics, South San Francisco, fed cuprizone to 3-month-old wild …
Taming ApoE Via the LDL Receptor Calms Microglia, Slows
2021年7月6日 · As an example: Cluster 2 is only represented by less than a dozen cells in the wild-type, LDLR, and ApoE knockout mice, and maybe two to four dozen cells in the P301S …
ApoE and Tau: Unholy Alliance Spawns Neurodegeneration
2017年4月15日 · To investigate this, graduate student Yang Shi crossed P301S mice, which express a tangle-forming FTD mutant of tau, to various ApoE knock-ins, as well as to ApoE …
Lack of Macrophage Protein Protects ApoE-Knockout Mice from
ApoE-knockout mice-which develop spontaneous hypercholesterolemia and atherosclerosis after about four months and neurodegeneration after eight months-crossed with aP2-knockout mice …
Sans TREM2, ApoE4 Drives Microgliosis and Atrophy in
2022年11月18日 · Previously, it was reported that the presence of human ApoE4 (in a mouse ApoE knockout background) in TauP301S mice (TE4) exacerbated tau-mediated …
ApoE: One Man’s Brain Can Do Without It - ALZFORUM
2014年8月22日 · Indeed, this is consistent with the findings on ApoE knockout mice. However, the mouse is a limited model in terms of neurocognitive function. The finding of essentially normal …