c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.

2018年2月19日 · In this review, we elaborate on the molecular structure of c-Met and HGF and the mechanism through which their interaction activates the PI3K/AKT, Ras/MAPK, and Wnt signaling pathways. We also summarize the connection between c-Met and RON and EGFR, which are also receptor tyrosine kinases.

MET transcription is activated by HGF and several growth factors. [42] MET promoter has four putative binding sites for Ets, a family of transcription factors that control several invasive growth genes. [42] ETS1 activates MET transcription in vitro. [43]

The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This review provides an overview of the evidence to support c-MET ...

2021年7月1日 · C-MET can be activated by either hepatocyte growth factor (HGF), or its natural isoform NK1. Here, we report the cryo-EM structures of c-MET/HGF and c-MET/NK1 complexes in the active state.

Topics covered include the c-MET signaling pathway, c-MET as a potential therapeutic target and biomarker, ongoing clinical trials evaluating c-MET-inhibiting drugs, and future directions in the laboratory and the clinical evaluation of c-MET-driven malignancies. Funding. Editorial assistance was funded by Daiichi Sankyo Europe GmbH.

2011年11月1日 · c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.