2024年12月12日 · IgE is an antibody that plays a key role in allergic responses. It can sometimes also be elevated for other reasons, such as chronic infections or inflammatory diseases. When your IgE levels are high, additional testing is often needed depending on your symptoms.

2023年8月28日 · Hyper IgE syndromes include rare primary immunodeficiency disorders distinguished by a triad of atopic dermatitis and chronic skin and lung infections with raised IgE levels. There is an impaired IL-10 and IL-21 signaling and eosinophilia.

2024年2月3日 · Elevated IgE levels above 1200 IU/mL can indicate increased risk for asthma, eczema, allergic rhinitis, food allergies, atopic dermatitis, allergic conjunctivitis, parasitic infections, and, rarely, immune disorders or cancers. Management: Consult an …

2025年1月20日 · Risks Associated with High IgE levels Severe allergic reaction-High IgE levels can increase the risk of severe allergic reactions, like anaphylaxis, which can be life-threatening. Cancer- High IgE levels have been associated with certain cancers, including non-Hodgkin lymphomas, oral cavity and pharynx cancer, and lung cancer.

2025年1月9日 · Very high serum IgE levels (≥1000 IU/mL) can be found in various atopic disorders, such as asthma. Very high IgE levels in adults are associated with increased risk of developing cardiovascular disorders (CVD), eosinophilic disorders and …

High Immunoglobulin E (IgE) levels can act as a compass in the realm of immunology, steering attention towards potential health issues. Defined as a class of antibodies, IgE plays a pivotal role in allergic responses and the body's defense against parasitic infections.

Elevated serum immunoglobulin E (IgE) can be caused by allergies, infections and immune conditions including hyper IgE syndrome (HIES). HIES is a rare primary immunodeficiency disease most commonly characterized by a triad of findings, including increased serum IgE levels, recurrent skin abscesses, and pneumonias leading to pneumatocele formation.

2023年10月17日 · Hyper-IgE syndrome is a hereditary combined B-cell and T-cell immunodeficiency characterized by recurrent staphylococcal abscesses of the skin, sinopulmonary infections, and severe pruritic eosinophilic dermatitis. Diagnosis is confirmed by measurement of serum IgE levels.

Many different syndromes are known to lead to high levels of an antibody called immunoglobulin E, or IgE. Many more such syndromes likely remain unknown. Collectively, these conditions are called hyper-IgE syndromes, or HIES. Other conditions, such as severe eczema, can lead to extremely high IgE levels that are not caused by a syndrome at all.

2019年2月11日 · High levels of total IgE can occur in allergic conditions, parasitic infections, certain immune-related disorders, and malignancies. The sensitivity of specific IgE tests ranges from 60% to 95% and the specificity from 30% to 95%, depending upon the type of allergen and the age of the patient [3].