Liver and drug metabolism: What role does it play?
2023年8月4日 · The liver plays a key role in the metabolism of drugs. The liver carries out phase 1 and phase 2 reactions to chemically alter drugs, making them more water-soluble.
Regulation of Hepatic Metabolism, Recent Advances, and Future ...
In this review we will describe recent advances in our understanding of how insulin and glucagon regulate liver metabolism under normal physiology as well as under pathophysiological …
Drug Metabolism - StatPearls - NCBI Bookshelf
2023年8月17日 · Drug metabolism occurs at a specific location in the body, resulting in a low concentration of active metabolites in the systemic circulation. This phenomenon is called first …
Drugs and the liver: Metabolism and mechanisms of injury
2024年7月30日 · The hepatic metabolism of drugs and the mechanisms by which drugs might injure the liver will be reviewed here. The different clinical patterns of drug-induced …
Biochemistry, Biotransformation - StatPearls - NCBI Bookshelf
2023年8月14日 · Biotransformation is a metabolic process that takes place mainly in the liver and helps to facilitate the excretion of both exogenous and endogenous substances. A series of …
Hepatic Metabolism in Liver Health and Disease - ScienceDirect
2017年1月1日 · Dysfunction of liver signaling and metabolism can cause metabolic liver disease such as nonalcoholic fatty liver disease (NAFLD) and/or type 2 diabetes. In this chapter, we …
Physiology, Liver - StatPearls - NCBI Bookshelf
2023年5月1日 · Due to its high perfusion, zone I plays a large role in oxidative metabolisms such as beta-oxidation, gluconeogenesis, bile formation, cholesterol formation, and amino acid …