Oxidation of Apolipoprotein B-100 in Circulating LDL Is Related to LDL …
2000年10月1日 · In FDB subjects, the presence of a mutant apoB-100 (FDB 3500Q) in LDL markedly reduced its affinity for the LDL receptor, leading to increased residence times (RTs) …
Possible Functional Interactions of Apolipoprotein B-100 …
1997年1月1日 · ApoB-100 has basic sequences, homologous with those of apoE, that form part of the apoB/E receptor–binding domain. These sequences of apoB-100 also interact with …
Structure of apolipoprotein B100 bound to the low-density lipoprotein ...
2024年12月11日 · Apolipoprotein B100 (apoB100) is a structural component of low-density lipoprotein (LDL) and a ligand for the LDL receptor (LDLR) 1. Mutations in apoB100 or in …
Human Apolipoprotein (Apo) B-48 and ApoB-100 Kinetics With …
1999年12月1日 · The mechanisms regulating the synthesis and secretion of apolipoprotein (apo) B-100 and apoB-48 are incompletely understood but are of importance because elevated …
Receptor binding activity of lipid recombinants of apolipoprotein B-100 ...
Apolipoprotein (apo) B-100, the protein constituent of low density lipoproteins (LDL), is the determinant responsible for LDL binding to the apoB,E (LDL) receptor on cells. The current …
The molecular structure of LDL has finally been elucidated
2024年12月11日 · LDL contains apolipoprotein B100 (apoB100), a large structural protein that interacts with the LDL receptor during endocytosis. ApoB100 is initially secreted by the liver on …
Apolipoprotein B100 - an overview | ScienceDirect Topics
When apolipoprotein B100, the major protein of circulating LDL, is chemically modified with reagents that derivatize lysine, it is taken up and degraded by macrophage scavenger …
Apolipoprotein B binding domains: evidence that they are cell ...
2011年4月15日 · Apolipoprotein B-100 (ApoB-100), the sole protein component of LDL, is known to bind to cell surface LDL receptor (LDLR) or cell surface-bound proteoglycans and to be …
ApoB100-LDL acts as a metabolic signal from liver to ... - PubMed
Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Thus, apoB100-LDL is a novel …
ApoB-100: The guardian of LDL stability - Atherosclerosis
2025年1月9日 · This structure is stabilized by a single apolipoprotein B-100 (apoB-100), which is anchored on the surface of the particle. This structure enables LDL particles to efficiently …