2024年6月6日 · Here, we investigate the phenomenon and mechanism of cellular uptake and intracellular fate of exogenous circRNAs. Human myeloid cells and B cells selectively internalize extracellular circRNAs. Macrophage uptake of circRNA is rapid, energy dependent, and saturable. CircRNA uptake can lead to translation of encoded sequences and antigen ...

2024年6月6日 · Here, we investigate the phenomenon and mechanism of cellular uptake and intracellular fate of exogenous circRNAs. Human myeloid cells and B cells selectively internalize extracellular circRNAs. Macrophage uptake of circRNA is rapid, energy dependent, and saturable. CircRNA uptake can lead to translation of encoded sequences and antigen ...

2021年12月7日 · Efferocytosis, macropinocytosis and phagocytosis together with diverse scavenger receptors (including CD36, SRA1/2, SRB1, SR-PSOX, LOX and LRP1) are involved in lipid uptake by macrophages .

2023年6月5日 · We show that in both human and mouse macrophages, reduced mCa 2+ uptake amplifies cytosolic Ca 2+ oscillations and potentiates downstream nuclear factor kappa B activation, which is central to...

2022年1月1日 · Lipid uptake is to a large extent facilitated by macrophage expressed scavenger receptors that are dynamically regulated and important in many metabolic diseases. Here, we review the receptors mediating lipid uptake and summarize recent findings on …

After cellular uptake, macrophages kill engulfed cells or organisms. Within the inflammatory process, macrophages, along with neutrophilic granulocytes, are the first line of cellular defense. Metchnikow hypothesized that the inflammatory reaction underwent evolutionary changes like any other biological process.

2015年8月1日 · Tools to dissect macrophages in organ-specific uptake, induction of toxicity and clearance in vivo are required to understand their current intrinsic lack of targeting, uncontrolled biodistributions, MPS accumulation, reduced circulation …

2022年6月1日 · Given the dominant role liver macrophages play in off-target uptake, it is critical to understand why they take up so many nanoparticles. This review article explores the advantages liver macrophages have in nanoparticle uptake in comparison to other cells and tissues.

If macrophage particle uptake correlates to nanomaterial in vivo performance, then understanding macrophage recognition of circulating foreign materials may help to elucidate how nanomaterials are cleared or elicit toxicity. Macrophages have evolved distinct pathogenic and foreign material recognition mechanisms [100–102]. These endogenous ...

2020年10月6日 · Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we review how macrophage lipid metabolism can be dynamically altered in different physiological and pathophysiological contexts and the key regulators involved.