Dynamic expression of genes in different types of endometrial cells illustrates their molecular response to embryos during implantation. Then, we developed a novel tool, ExtraCellTalk, generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as …

Dynamic expression of genes in different types of endometrial cells illustrates their molecular response to embryos during implantation. Then, we developed a novel tool, ExtraCellTalk, generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as …

2024年5月11日 · Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium, identifying 4 different lineages in embryos and 13 cell types in the endometrium.

2024年5月13日 · 该研究成果“Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy”发表在知名期刊Science China Life Sciences（影响因子9.1）。

2024年5月13日 · 近日，我校动物科学学院吴珍芳教授团队在妊娠早期母胎互作调控猪胚胎着床方面取得重要研究进展，揭示了猪胚胎着床过程中胚胎与母体子宫内膜细胞组分变化、基因时空表达规律以及母胎信号传导新机制。 该研究成果“Dynamic intrauterine crosstalk promotes porcine embryo implantation during early...

2019年11月21日 · Several primary molecules, such as mucins, integrins and CDs, have been shown in regulation of various cell adhesion cascades for the embryo implantation in pigs [9–12]. Among the adhesion molecules, integrin family members serve as receptors for various extracellular matrix (ECM) ligands.

2015年12月21日 · In this study, we use RNA-Seq to analyze the responses of the porcine endometrium to conceptus signals on day 12 (the time of maternal recognition), day 18 (conceptus attachment), and day 25 (embryo implantation) of pregnancy.

2022年9月17日 · This review describes four regulatory mechanisms of epigenetics involved in porcine embryonic development: DNA methylation, histone modification, non-coding RNA function, and chromatin accessibility, and explores the possible crosstalk between them.

Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell tran- scriptome of pig peri-implantation embryos and corresponding maternal endometrium, identifying 4 different lineages in embryos and 13 cell types in the endometrium.

In the present study, injection of the uterine horn with LIFR-specific inhibitor EC359, revealed that LIFR knockdown inhibited embryo implantation, leading to an increased risk of implantation failure. A recent study has shown that cell proliferation and migration genes are up-regulated during embryo implantation.