In an ideal mouse system, one could quickly generate tumors resembling human tumor cells at both the genetic and morphologic levels. Accomplishing this using mouse models has …

2019年6月24日 · Fundamental to the discovery and development of anticancer drugs is the ability to model tumour growth, recapitulating elements and characteristics of the human disease in …

Recently, humanized mouse xenograft models that accept patient-derived xenografts and CD34+ cells were developed to better mimic tumor heterogeneity, the tumor microenvironment, and …

2022年7月20日 · We then describe in more detail the subcutaneous tumor model and key steps needed to establish it in the laboratory, namely: choosing the mouse strain and tumor cells; …

Here, we review the evolution of preclinical mouse models and their utility as coclinical platforms for mechanistic interrogation of cancer immunotherapies. Recent years have seen dramatic …

Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene functions, identifying novel …

2016年9月30日 · Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies — each with their specific advantages and difficulties — have laid the …

2020年6月9日 · This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of …

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer. We focus on: spontaneous and induced tumors in mice; genetically defined mouse …

The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology database) integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, …

Xenograft mouse tumor models involve the transplantation of human cancer cells or solid tumors into an immunocompromised host mouse strain to avoid rejection of the cancer transplant.

2022年10月14日 · Using transcriptomic and experimental variables from >700 ICB-treated/control syngeneic mouse tumors, we developed a machine learning framework to model tumor …

The simplest tumour model is the subcutaneous model, in which cell lines initially derived from human tumours (xenograft model) or mouse tumours (syngeneic model) are typically …

In this review, we will discuss the major classes of experimental mouse models of cancer commonly used for immunotherapy assessment and provide examples to guide the selection …

2023年1月4日 · Scientists develop cell therapy engineered to kill and prevent brain cancer in advanced mouse model Scientists at Brigham and Women’s Hospital are harnessing a new …

2021年6月4日 · Mouse model is a powerful tool to integrating basic and clinical tumor research and has been used in various fields of oncology. A successful tumor model should meet the …

2011年12月2日 · Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel …

2023年7月1日 · Genetically engineered mouse (GEM) models have the requisite tumor microenvironment to recapitulate human cancers. Efforts are ongoing to overcome the …

2025年1月24日 · Treatment with U4-I05 also inhibited tumor metastasis and extended survival in a genetically engineered CRC mouse model. This study identifies U4-I05 as a USP4 inhibitor …

Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered …

2 天之前 · Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse …

2022年1月7日 · Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity …

We suggest that xenografts should no longer be referred to as mouse cancer models. Xenografts represent an intermediate step between cell culture and mouse cancer models, and could be …

2025年1月23日 · "It is very rare for a compound to shrink tumors in mouse models of breast cancer, let alone completely eradicate those tumors with a single dose, so we are eager for …

Studies of cancer preventive agents requires xenografts of human normal breast tissue or carcinoma-in-situ lesions, or alternatively mouse or rat models that develop tumors, either …

2025年1月16日 · Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in …

2 天之前 · Moreover, TM treatment demonstrated great anti-tumor effects on androgen‐independent cells, DU145 and PC-3 cells. TM inhibited their proliferation, migration, …

2025年1月22日 · In a cancer mouse model, wrinkling patterns in bladder-lining tissue differ from their healthy counterparts. Changes in tissue-mechanical properties that alter elastic buckling …