The MMRRC is the nation’s premier national public repository system for mutant mice. Funded by the NIH continuously since 1999, the MMRRC archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by the biomedical research community.

2022年11月1日 · Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity. Known as inhibitory synapses, these neural connections are rebalanced so that we can consolidate new information into long-lasting memories during sleep.

2025年1月2日 · Knockout mice are a powerful tool to study gene function and nervous system physiology, given the genomic similarity between mice and humans. The trans-NIH funded Knockout Mouse Project (KOMP) was launched in 2006 to support the generation of a comprehensive resource in mouse Embryonic Stem (ES) cells …

The Mutant Mouse Resource & Research Centers (MMRRC) is NIH’s premier national mouse repository that consists of four Centers (University of California, Davis; University of Missouri; University of North Carolina at Chapel Hill; and The Jackson Laboratory) and one Informatics, Coordination and Service Center (ICSC).

Over the next five years, National Institutes of Health (NIH)-funded researchers will extensively test and generate data about mice with disrupted genes to gain clues about human diseases. NIH today awarded a set of cooperative agreements totaling more than $110 million to begin the second phase of the Knockout Mouse Project (KOMP).

2019年8月1日 · NIH researchers create mouse colony to address shortcomings of laboratory mice. Researchers at the National Institutes of Health developed a new mouse model that could improve the translation of research in mice into advances in human health.

2021年7月27日 · The Mutant Mouse Resource and Research Center (MMRRC) Program is the pre-eminent public national mutant mouse repository and distribution archive in the USA, serving as a national resource of mutant mice available to …

The mouse lines are the latest addition to the Cre Driver Network, an initiative to create a collection of mouse strains that offer scientists the ability to make precise alterations in brain-related genes as a way of exploring their impact on brain function. The network is funded by the NIH Blueprint for Neuroscience Research. Background

2019年8月19日 · Using a mouse model of stuttering, scientists report that a loss of cells in the brain called astrocytes are associated with stuttering. The mice had been engineered with a human gene mutation previously linked to stuttering.

As part of its ongoing effort to build a public, genome-wide library of “knockout” mouse models for the study of human disease, the National Institutes of Health (NIH) today awarded $800,000 to two public mouse repositories to acquire genetically engineered mouse lines not yet widely accessible to researchers.