2024年10月7日 · This study demonstrated the capacity of p62 to monogenically regulate the obesity phenotype and emphasized its dual role in managing energy homeostasis through direct modulation of STAT3/POMC signaling and amplification of leptin sensitivity.

2015年11月9日 · The addition of IL-6 to starved U937 cells significantly activated the phosphorylation level of STAT3 (p-STAT3) at Tyr705 and reduced the protein levels of microtubule-associated protein 1...

目的 探讨STAT3 和自噬相关蛋白Beclin1、p62、LC3B在结肠癌组织中的表达情况,并分析它们之间的相关性.方法 免疫组化方法检测结肠癌组织(n=86)、癌旁组织(n=86)及正常结肠组织(n= 86)包埋蜡块中 STAT3、Beclin1、p62、LC3B 的阳性表达率,并分析 STAT3 与自噬指标在结肠癌中 ...

New data obtained from the laboratory of Guido Kroemer identifies STAT3 as a new autophagy regulator. In the cytoplasm, in the absence of conventional phosphorylation on the tyrosine 705 residue, STAT3 interacts with the PKR kinase to inhibit eIF2A phosphorylation and so reduce autophagic pathways.

Blocking STAT3 phosphorylation by chemical inhibitor AG490 induced HDAC1 down-regulation followed by increases in Atg3 and LC3-II/LC3-I. Interestingly, we also found that AG490 treatment enhanced P62 expression in high glucose-stimulated RSC96 cells.

2021年8月24日 · The regulation of apatinib on VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling were detected. Furthermore, we collected conditioned medium (CM) from A549 and H1299 cells to stimulate phorbol myristate acetate (PMA)-activated THP-1 cells, and examined the effect of apatinib on PD-L1 expression in macrophages.

蛋白质印迹用于检查辐射反应蛋白 STAT3 和 p-STAT3、衰老相关蛋白 p62 和 GATA4、自噬相关蛋白 Beclin1 和 LC3-II/LC3-I 的变化。 通过实时聚合酶链反应检测 SASP 因子

We report here that the phosphorylation of p62, a glycoprotein nucleoporin of the nuclear pore complex (NPC), by MAP kinase is involved in this process. Ang II caused a time-dependent translocation of signal transducers and activators of transcription (STAT3) from the cytoplasmic compartment into the nucleus.

3 天之前 · SQSTM1/p62 sequesters KEAP1 (kelch-like ECH-associated protein 1), an adaptor protein for the CUL3 (cullin 3)-RBX1 (ring-box 1)-dependent E3 ubiquitin ligase complex. This sequestration protects NFE2L2/NRF2 (nuclear factor, erythroid derived 2, like 2) from degradation. ... Immunoblotting of proteasomal transcription factor proteins STAT3, ...

2022年6月6日 · Reconstitution of STAT3-KO cells with WT-STAT3 restored p62 gene expression confirming that STAT3 regulates p62 at the transcriptional level in MT330 cells. In contrast, p62 gene expression was unaltered in STAT3-KO and …