2022年1月10日 · Hereto, male hyperlipidemic low-density lipoprotein receptor knockout mice were fed an atherogenic Western-type diet and injected 3 times per week intraperitoneally with PRMT3 inhibitor...

2023年8月28日 · In this study, we identified that PRMT3 catalyzes asymmetric arginine dimethylation of RIG-I, MDA5, and cGAS, leading to the inhibition of their activation. As a result, knockdown of Prmt3 in mice can protect mice against both RNA and DNA virus infection. Our results suggest that PRMT3 is a negative regulator of cytosolic RNA and DNA sensors.

2024年9月10日 · Genetic depletion or pharmacological inhibition of PRMT3 elicits an influx of T cells into tumors and reduces tumor size in HCC mouse models. Mechanistically, PRMT3 methylates HSP60 at R446...

The role of PRMT3 in renal fibrosis was studied in vivo in the UUO mouse model using Prmt3 gene knockout mice. The birth rate of homozygous (Homo) Prmt3 knockout mice is low (less than 10% of pups). Prmt3 Homo knockout mice have low body weight after weaning but can catch up normal body weight in adulthood.

Chronic treatment of hyperlipidemia ApoE-knockout mice with the allosteric PRMT3 inhibitor SGC707 effectively reduced the degree of hepatic steatosis and significantly reduced the expression level of lipoprotein lipase mRNA in adipocytes . This finding indicates that PRMT3 is an intermediate factor that strongly and selectively affects the ...

2022年1月10日 · Schematic overview of the effect of PRMT3 inhibitor SGC707 treatment in LDL receptor knockout mice. Inhibition of the PRMT3 activity by SGC707 is associated with a decrease in transcript levels of gene involved in lipogenesis and a parallel reduction in hepatic triglyceride stores and plasma VLDL-triglyceride levels.

2019年12月10日 · The knockout of PRMT2 resulted in lean, hypophagic mice with reduced serum leptin levels, which suggests that PRMT2 has an important role in obesity and obesity-related syndromes . Furthermore, in neurological function, PRMT2 can methylate the actin nucleator Cobl to regulate neuronal morphogenesis and dendritic arborization in the central ...

2019年6月1日 · To establish that PRMT3 inhibition can diminish the Western-type diet-induced (LXR-driven) hepatic steatosis development, we investigated liver morphology in atherogenic diet-fed apoE knockout mice after 6 weeks of parallel treatment with SGC707.

2023年11月16日 · Knockdown of PRMT3 increased lipid peroxidation levels in cells and accelerated tumor ferroptosis, all of which inhibited resistance to ferroptosis in EC. Clinical data further supported the high expression of PRMT3, the low expression of METTL14, and the negative correlation between the two in EC patients.

2023年4月6日 · To examine the effect of PRMT3 KO on the response of HCC cells to OXA in vivo, we subjected tumor-bearing mice implanted with PRMT3-KO and -WT PLC-8024 cells to vehicle or OXA treatment (Supplementary Fig. 3a). We found that PRMT3 KO dramatically sensitized PLC-8024 cells to OXA treatment, as shown …