2008年5月1日 · We have demonstrated that a subset of human leukemias have mutations in the nSMase gene SMPD3, which encode the major catalytic enzyme responsible for the …

2020年10月8日 · Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, is a crucial enzyme involved in multiple cell regulatory...

Neutral sphingomyelinase SMPD3 (nSMase2), a sphingomyelin phosphodiesterase, resides in the Golgi apparatus and is ubiquitously expressed. Gene ablation of smpd3 causes a generalized …

2024年12月25日 · Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and …

2005年3月11日 · Neutral sphingomyelinases sphingomyelin phosphodiesterase (SMPD)2 and -3 hydrolyze sphingomyelin to phosphocholine and ceramide. smpd2 is expressed ubiquitously, …

2008年5月1日 · Ceramide is a lipid second messenger derived from the hydrolysis of sphingomyelin by sphingomyelinases (SMases) and implicated in diverse cellular responses, …

2024年2月1日 · To gain insight into how neural crest cells regulate their lipid content at the transcriptional level during EMT, here we identify critical enhancer sequences that regulate the …

The SMPD3-produced exosomal CER critically conducted the intercellular transfer of CER from the hepatocytes to metastatic CRC cells and impeded CRLM by inducing mitochondrial …

2005年3月22日 · Neutral sphingomyelinases sphingomyelin phosphodiesterase (SMPD)2 and -3 hydrolyze sphingomyelin to phosphocholine and ceramide. smpd2 is expressed ubiquitously, …

Induction of liver regeneration (LR) resulted in significant up-regulation of hepatic sphingomyelin phosphodiesterase 3 (SMPD3). SMPD3-produced exosomal ceramide (CER) constitutes a …