2023年7月10日 · Building on prior mathematical modeling of the TEB 4 and experimental evidence for cellular intercalation in mammary organoids, 5 Pfannestein and Macara 1 now reveal that luminal cell intercalation within the TEB is essential and accounts for 80% of …

2023年7月10日 · In this issue of Developmental Cell, Pfannenstein and Macara leverage the experimental versatility of the mammary gland to show that intercalation within the terminal end bud is regulated by the tight junction organizing protein ZO-1 and dynamic actin cytoskeletal rearrangements to propel ductal elongation.

2023年7月10日 · How ductal epithelial organization arises in the mammary gland from multilayered terminal end buds (TEBs) is not well understood. Pfannenstein et al. show body cells within the TEB intercalate to form monolayers and generate ductal elongation, a process that involves junctional and cytoskeleton rearrangements.

initiates the formation of the club-shaped TEB structures that eventually drive the establishment of the epithelial bilayer, which is comprised of inner luminal cells and outer myoepithelial cells that are concomitant with extension and branch-ing of the fully arborized ductal network in the breast.2 Importantly, these club-like TEB structures a...

The terminal end bud (TEB) is the growing part of the ductal mammary epithelium during puberty, enabling the formation of a primary epithelial network. These highly proliferative bulbous end structures that drive the ductal expansion into the mammary fat pad comprise an outer cap cell layer, contain …

2017年2月6日 · Formation of the ductal tree is orchestrated by a specialized structure called the terminal end bud (TEB). The TEB is responsible for the production of mature cell types leading to the elongation of the subtending duct. The TEB is also the regulatory control point for basement membrane deposition, branching, angiogenesis, and pattern formation.

2016年10月10日 · Mammary gland ductal elongation is spearheaded by terminal end buds (TEBs), where populations of highly proliferative cells are maintained throughout post-pubertal organogenesis in virgin mice until the mammary fat pad is filled by a mature ductal tree.

independent cell proliferation drives bud elongation to form a mammary sprout. This sprout grows out of the condensed mammary mesenchyme and invades into the underlying fat

al., 1983). The TEB contains two histologically distinct cell types: the body cells and the cap cells. The cap cells are the outermost layer of the TEB and interact through a thin basal lamina with the surrounding stroma. Cap cells are thought to be the progenitors for …

2017年6月1日 · Formation of the ductal tree is orchestrated by a specialized structure called the terminal end bud (TEB). The TEB is responsible for the production of mature cell types leading to the...