alpha 2-Macroglobulin (alpha 2M) in the rat is a strong-reacting acute-phase protein with potent protease-inhibiting and cytokine-binding properties. Production of alpha 2M is ascribed mainly to liver parenchymal cells. In the present study, we investigated, by …

Sep 1, 2011 · In contrast, I/R-2m and MI-2m rats exhibited dilated LV with increased ventricular volumes and reduced ESPVR. Cardiac function correlated inversely with MI size. The sequential 2 mo of Ab and 30 min coronary artery ischemia with 2 mo of reperfusion in Ab + I/R hearts resulted in high ESPVR and LV pressure similar to Ab-4m rats, but with ...

Exogenously administered, purified rat alpha 2 macroglobulin (alpha 2M, recognized as an acute phase reactant with anti-inflammatory properties) greatly inhibits the increase of the pulmonary resistance during the antigen-induced bronchoconstriction in rats in vivo, whereas a BaSO4 pretreatment (a method to induce a broad spectrum of serum ...

Apr 20, 1994 · The alpha 2-macroglobulin (alpha 2M), a protease inhibitor, is a major acute-phase protein in rats, and is produced in the liver during acute inflammation. Recently, it has been demonstrated that alpha 2M is also produced by cultured astrocytes from newborn rat brain and has neurite-promoting activi …

Apr 1, 1994 · The magnitudes of increase in concentrations of circulating Hp, TST, Hx and AGP in rats pretreated with ~2M or saline were similar and lower than those in sublethally injured rats.

Jan 5, 1987 · Rat blood plasma contains three high molecular weight thiol ester-containing proteinase inhibitors, alpha 1-macroglobulin (alpha 1M), alpha 1-inhibitor III (alpha 1I3), and alpha 2-macroglobulin (alpha 2M). Rat serums have been analyzed using a two-dimensional gel electrophoretic technique which optimizes recovery of high molecular weight ...

Jan 1, 2025 · Extracts from 2M (and to some extent 6M) rats strongly reduce the toxicity of α-Syn in cells as well as the associated increase in ROS, while 9M and 14M extracts have little, if any effect (Fig. 7 a-d).

Exogenously administered, purified rat alpha 2 macroglobulin (alpha 2M, recognized as an acute phase reactant with anti-inflammatory properties) greatly inhibits the increase of the pulmonary resistance during the antigen-induced bronchoconstriction in rats in vivo, whereas a BaSO4 pretreatment (a method to induce a broad spectrum of serum ...

Mar 30, 2011 · The most significant observation implicating the direct involvement of HLA-B27 in SpAs has come from HLA-B27 transgenic rats. Several HLA-B27-human β 2m rat transgenic lines developed a spontaneous multisystemic inflammatory arthritic disorder with many features of human AS [ 5 , 6 ].

The effect of alpha 2-macroglobulin (alpha 2M) administration on the survival rate of lethally injured rats and molecular mechanisms regulating its hepatic expression after sublethal and lethal scalding were examined. Transcriptional activity of nuclei for the alpha 2M gene increased after a …