ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. [5] This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.

Pancreatic β-cell specific Abca1 KO mice (Abca1-P/-P) showed age-related and gene-dose-dependent accumulation of cholesterol in β-cells. In addition, these mice showed significantly decreased insulin secretion in response to an acute glucose challenge in vivo, along with progressive glucose tolerance impairment, which was not related to islet ...

The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. Learn about this gene and related health conditions.

2022年8月16日 · ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).

2024年12月24日 · ABCA1 (ATP Binding Cassette Subfamily A Member 1) is a Protein Coding gene. Diseases associated with ABCA1 include Tangier Disease and Hypoalphalipoproteinemia, Primary, 1. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Cholesterol metabolism.

2025年1月4日 · ABCA1 R219K polymorphism is a protective factor of coronary heart disease in Asians, but not in Caucasians. ABCA1 impacts athero-thrombotic risk and has a role in secondary prevention; ABCA1 genetic variation may have a role in risk of cardiovascular disease

The ABCA1 gene, a member of the ATP-binding cassette A (ABCA1) transporter superfamily, encodes a membrane protein that facilitates the cellular efflux of cholesterol and phospholipids. Mutations in ABCA1 lead to familial high density lipoprotein deficiency and Tangier disease.

2022年3月3日 · ATP-binding cassette transporter A1 (ABCA1) utilizes energy derived from ATP hydrolysis to export cholesterol and phospholipids from macrophages.

2012年11月9日 · ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol (FC) from tissues by effluxing cellular FC and phospholipids to lipid-poor apolipoprotein A-I. Macrophage ABCA1 also dampens pro-inflammatory MyD88-dependent Toll-like receptor signaling by reducing cellular membrane FC and lipid raft ...

To explore the specific role of ABCA1 in macrophages in vivo and in vitro, we generated macrophage-specific ABCA1 knockout (Abca1-M/-M) mice. Using this unique mouse model, we demonstrated that macrophages from Abca1 -M/-M mice have a significant increase in FC and are more proinflammatory in vivo and in vitro in response to LPS via TLR4 ...