2021年3月16日 · One of the most significant genetic risk factors is a form of the apolipoprotein E gene called APOE4. About 25% of people carry one copy of APOE4, and 2 to 3% carry two copies. APOE4 is the strongest risk factor gene for Alzheimer’s disease, although inheriting APOE4 does not mean a person will definitely develop the disease.

2024年8月21日 · The APOE4 gene increases your risk of developing Alzheimer’s disease. The test results aren’t a diagnosis. Instead, they identify a risk factor that may contribute to the condition’s development. What is an APOE gene test? An APOE gene test is a type of genetic test that identifies which variant of the apolipoprotein E (APOE) genotype you have.

2024年6月7日 · But the new study, published in May in the journal Nature Medicine, found that 95% of carriers developed signs of AD in their brain or body fluids. And those signs were evident, on average,...

2022年5月31日 · Researchers have discovered that a rare mutation inherited with the APOE4 gene variant protects against Alzheimer's, shedding new light on ways to counteract high-risk genes for the disease.

2024年9月12日 · Led by Columbia University researchers, an international scientific team analyzed DNA sequences of cognitively healthy older adults with APOE ε4 to determine if they had another gene that was protecting them from developing Alzheimer’s.

Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. [5] . It is encoded in humans by the gene APOE. Apo-E belongs to a family …

APOE-ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and is associated with an increase in the levels of amyloid deposition and an early age of onset. Recent data demonstrate that AD pathological changes occur decades before clinical symptoms, raising questions about the precise onset of the disease.

2024年1月8日 · Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD...

With 25% of the population being APOE4 carriers, understanding the role of this allele in AD pathogenesis and pathophysiology is crucial.

In this review, we discuss genetic and epigenetic regulatory mechanisms controlling and influencing APOE expression and focus on interactions of APOE and TREM2 in the context of microglia and astrocytes’ role in AD-like pathology in animal models. Keywords: Alzheimer’s disease, risk, APOE, TREM2, transcriptional control, animal model.