ApoE plays many important roles in lipoprotein/ cholesterol metabolism, participates in lipid transport in CNS, and can indirectly regulate Aβ metabolism, as well as directly interact with Aβ...

Apolipoprotein E (ApoE) is a 34-kDa circulating glycoprotein, secreted by the liver and macrophages with pleiotropic antiatherogenic functions and hence a candidate to treat hypercholesterolaemia...

Three genotypes of the ApoE gene (ApoE ε2, ε3, ε4) were obtained based on the combination of ApoE rs429358 and ApoE rs7412 polymorphisms. Participants were asked to self-report the...

The gene, APOE, is mapped to chromosome 19 in a cluster with the apolipoprotein C1 (APOC1) gene and the apolipoprotein C2 (APOC2) gene. The APOE gene consists of four exons and three introns, totaling 3597 base pairs.

2024年12月24日 · APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with APOE include Lipoprotein Glomerulopathy and Hyperlipoproteinemia, Type Iii. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Statin inhibition of cholesterol production.

Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2.

2025年1月4日 · This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided ...

The APOE gene exists in three principal allele forms: ε2, ε3, and ε4, creating a genetic variant that influences the protein’s structure and function. These alleles determine the individual’s APOE genotype, which can be combinations of the three alleles (e.g., ε3/ε3, ε3/ε4, ε4/ε4). ε2 …

Positions based on the mature protein, 299 amino acids long, appear in gray (diagram) and in parentheses (table). References for ApoE domains and regions can be found in Methods. Click on the amino acids in the diagram or on the “Additional Variants” box in the lower-right-hand corner. You can also click on the variants in the table below.

2025年1月22日 · The apolipoprotein E (APOE) gene, located on chromosome 19, remains the primary genetic factor associated with late-onset Alzheimer's disease. 1 In European populations, the ε4 haplotype of APOE, present in approximately 14% of individuals, significantly increases Alzheimer's disease risk, while the less common ε2 haplotype (∼8%) appears to confer a protective effect. 2 Despite its ...