2012年4月1日 · Endothelial overexpression of Nox2 in ApoE −/− mice did not alter blood pressure, but significantly increased vascular superoxide production compared with ApoE −/− littermates, measured using both lucigenin chemiluminescence and 2-hydroxyethidium production (ApoE −/−, 19.9 ± 6.3 vs. Nox2-Tg ApoE −/−, 47.0 ± 7.0 nmol 2 ...

2023年8月1日 · We generated a vulnerable carotid plaque model induced by carotid branch ligation and renal artery constriction, combined with a high-fat diet in ApoE −/− mice. NOX2 specific inhibitor, GSK2795039 (10 mg/kg/day by intragastric administration for 8 weeks) significantly prevented vulnerable plaque, evaluated by micro-ultrasound imaging ...

Nox2 expression was upregulated in the aortic endothelium of ApoE(-/-) mice before the appearance of lesions, and this was associated with elevated ROS levels. Within developing plaques, macrophages were also a prominent source of Nox2.

2010年2月18日 · Background and Purpose— We tested the hypothesis that elevated superoxide production by Nox2-NADPH oxidase occurs in cerebral arteries during hypercholesterolemia and causes decreased nitric oxide function. Methods— Wild-type (WT), apolipoprotein E-deficient (ApoE −/−) and Nox2 −/− /ApoE −/− mice were fed a high-fat diet for 7 to 14 weeks.

nadph氧化酶2（nox2）是巨噬细胞中ros的主要来源，在动脉粥样硬化的形成中起着至关重要的作用。 然而，NOX2 抑制对已建立的易损斑块的影响以及所涉及的潜在作用仍不清楚。

2012年2月23日 · Douglas et al. describe ApoE −/− mice with endothelial-targeted overexpression of human Nox2 (Nox2-Tg ApoE −/− ). 7 The key findings of this study are that increased endothelial ROS production leads to enhanced vascular cell adhesion molecule-1 levels and increased monocyte/macrophage recruitment at 9 weeks of age.

2012年2月26日 · Endothelial overexpression of Nox2 in ApoE (-/-) mice did not alter blood pressure, but significantly increased vascular superoxide production compared with ApoE (-/-) littermates, measured...

在这里，我们研究了 Nox2 抑制对晚期动脉粥样硬化和 2 型糖尿病患者的隐静脉 EC (SVEC) 中超氧化物生成的治疗潜力，以及对载脂蛋白 E 缺陷 (ApoE) 患者的血管功能、血管损伤和脂质沉积的治疗潜力。

2012年1月27日 · Endothelial-targeted Nox2 overexpression in ApoE−/− mice is sufficient to increase vascular superoxide production and increase macrophage recruitment possible via activation of endothelial cells, indicating that Nox-mediated reactive oxygen species signalling has important cell-specific and distinct temporal roles in the initiation and ...

2012年10月31日 · We have previously shown that deletion of the Nox2 gene in ApoE −/− mice affords protection against endothelial dysfunction and atherosclerotic lesion development . Deletion of the Nox2 gene in these animals would have resulted in a …