Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. [5]

2021年4月15日 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ₄₂, which aggregates into bioactive conformational species and likely initiates toxicity in …

2024年12月24日 · BACE1 (Beta-Secretase 1) is a Protein Coding gene. Diseases associated with BACE1 include Alzheimer's Disease and Myositis. Among its related pathways are Alzheimer's disease and miRNA effects and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include enzyme binding and endopeptidase activity.

β-分泌酶1，也称为 β位淀粉样前体蛋白裂解酶1 、 β位APP裂解酶1 （BACE1）、 膜相关天冬氨酸蛋白酶2 、 memapsin-2 、 天冬氨酰蛋白酶2 和 ASP2，是一种酶，在人类中由BACE1 基因 编码。 [5] BACE1的表达主要在 神经元 中观察到。 BACE1是一种 天冬氨酸蛋白酶，对周围神经细胞中 髓鞘 的形成很重要：在小鼠中，当发生髓鞘形成时，BACE1的表达在产后阶段很高。 [6] 跨膜蛋白 在其细胞外 蛋白质结构域 中含有两个活性位点 天冬氨酸 残基，可作为 二聚体 发挥作用，其 …

2007年11月15日 · BACE1 cleavage of APP is a pre-requisite for Aβ formation. Aβ genesis is initiated by BACE1 cleavage of APP at the Asp+1 residue of the Aβ sequence to form the N-terminus of the peptide. This scission liberates two cleavage fragments: a secreted APP ectodomain, APPsβ and a membrane-bound carboxyl terminal fragment (CTF), C99.

Full length APP is a type 1 integral-membrane protein. It has two processing pathways: Minor amyloidogenic (10%) and major nonamyloidogenic (90%). In the amyloidogenic pathway, β-secretase (BACE-1) cleaves the luminal domain of APP at …

这种跨膜蛋白酶催化淀粉样蛋白前体蛋白形成淀粉样蛋白 β 肽的第一步。 淀粉样蛋白 β 肽是淀粉样蛋白 β 斑块的主要成分，它在人类阿尔茨海默病患者的大脑中积累。 [RefSeq 提供，2015 年 11 月] This gene encodes a member of the peptidase A1 family of aspartic proteases.

2024年11月2日 · Title: Serum Beta-Secretase 1 Activity Is a Potential Marker for the Differential Diagnosis between Alzheimer's Disease and Frontotemporal Dementia: A Pilot Study. Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease.

2025年1月4日 · beta secretase, widely known as beta-site amyloid precursor protein cleaving enzyme (BACE)1 initiates production of the toxic amyloid beta (Abeta) that plays a crucial early part in Alzheimer's disease pathogenesis.

The β-secretase enzyme, also known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is required for production of the β-amyloid (Aβ) peptide that has a crucial early role in Alzheimer’s disease (AD) pathogenesis. β-Secretase/BACE1 is a prime therapeutic target for reducing cerebral Aβ levels, and the development of BACE1 ...