2023年5月24日 · Mesenchymal stem/stromal cells (MSCs) are of the most responsive cell populations to inflammation in tissues. MSCs are a kind of tissue stem cells that were initially identified in the...

Bone marrow mesenchymal stem cells (MSCs), also named bone marrow stromal cells, are pluripotent stem cells that localize in the stromal compartment of the bone marrow, where they support hematopoiesis and differentiate into mesenchymal lineages [261–266].

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do …

MSCs are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs have been identified as an adherent, fibroblast-like population, originally isolated from BM [2].

2023年3月31日 · Bone marrow (BM)-derived mesenchymal stromal/stem cells (MSCs), which is characterized by non-hematopoietic, plastic-adherent, colony-forming cells, were first identified by Friedenstein and...

2019年4月12日 · The research on bone marrow-derived stem cells of connective tissue is evolving and continuously expanding with a recent boost of interest in clinical applications reflected by an avalanche of nearly 1,000 registered clinical trials.

Mesenchymal stem cells (MSCs) are multi-potent cells that derive from the bone marrow, migrate to sites of injury, promote bone regeneration and can inhibit immune responses. In vitro , MSCs can differentiate into mesodermal cells—osteoblasts, adipose cells and cartilage cells.

Bone marrow mesenchymal stem cells (MSCs) are different from other somatic stem cells in that they differentiate not only into the same mesodermal-lineage such as bone, cartilage, and adipocytes but also into other lineages of ectodermal and endodermal cells.

It was shown as long as half a century ago that bone marrow is a source of not only hematopoietic stem cells, but also stem cells of mesenchymal tissues. Then the term of mesenchymal stem cells (MSCs) has been coined in early 1990s and over a decade ...

This review describes the historical emergence of the concept of bone marrow mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic inductive microenvironment; Dexter's hematopoiesis-supportive stromal cells; Friedenstein's osteogenic cells; and Pittenger's trilineal osteoblastic, chondrocytic, and adipocytic ...