Calpain Knockout Mice

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Nature
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Protective role of endothelial calpain knockout in
To explore the role of calpain and its signaling pathway in lipopolysaccharide (LPS)-induced acute kidney injury (AKI), animal models of endotoxemia were established by administration of LPS to mice with end… 展开
Introduction
Acute kidney injury (AKI) is one of the major components of multiorgan dysfunction syndrome (MODS). Sepsis is a life-threatening condition of organ dysfunction caus… 展开
Nature
Materials and methods
Animals
Breeding pairs of C57BL/6 mice were purchased from The Jackson Laboratory (Sacramento, CA USA), and transgenic Tg-CAST mice wer… 展开
Nature
Results
LPS-induced renal injury was alleviated in mice with Capn4 knockout
The endotoxemia models were established by intraperitoneal injection of LPS (4 mg/kg), and the … 展开
Nature
Discussion
This study is the first to report that endothelial cell-specific Capn4 knockout reduced LPS-induced renal dysfunction and that this protective effect may be attributed to attenuated ap… 展开
Nature
Does LPs treat calpastatin overexpression and myeloid-specific CAPN4 knockout?
In addition, mice with calpastatin overexpression (Tg-CAST) and myeloid-specific Capn4 knockout (LYZ/Capn4 −/−) were also treated with LPS, and changes in kidney injury were assessed. BUN concentrations in plasma ( f and h) and caspase-3 activity ( g and i) in kidney tissue were detected.
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Inhibiting calpain 1 and 2 in cyclin G associated …
2020年11月19日 · Podocyte-specific deletion of Capns1, essential for calpain-1 and calpain-2 activities, also improved proteinuria and glomerulosclerosis in …
作者: Xuefei Tian, Kazunori Inoue, Yan Zhang, Ying Wang, C. John Sperati, Christopher E. Pedigo, Tingting ...
Publish Year: 2020
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Double knockouts reveal that protein tyrosine phosphatase 1B is a ...
Further evaluation of mutant mice by the ferric chloride-induced arterial injury model suggests that the Capn1-/- mice are relatively resistant to thrombosis in vivo. Together, our results …
标记:
Calpain-1
Protein Tyrosine Phosphatase
Publish Year:2007
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Calpain-1 Up-Regulation Promotes Bleomycin-Induced
2024年12月1日 · In this study, in calpain-1 knockout mice, MDL-28170 (a calpain-1 inhibitor) and murine lung epithelial-12 (MLE-12) cells overexpressing calpain-1 were used to confirm the …
标记:
Calpain-1
Pulmonary fibrosis
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Calpain-mediated regulation of platelet signaling pathways
The first direct evidence for a functional role of calpains in platelets came from the generation of calpain-1 knockout mice, which show a reduced platelet aggregation and clot retraction …
Nature
https://www.nature.com › articles
Targeted inhibition of endothelial calpain delays wound healing by ...
2020年7月14日 · Using a mouse genetic model where Capns1 is deleted only in endothelial cells, we showed that calpain-1/2 disruption is associated with reduced injury-activated …
标记:
Calpain-1
Publish Year:2020
Calpain Inhibitor Review
Calpain Activity
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Does calpain activation exert a proapoptotic effect in mice with sepsis?
Calpain activation exerts a proapoptotic effect in mice with sepsis and in LPS-treated cultured cells, including cardiomyocytes and endothelial, diaphragm and skeletal muscle cells 16, 17, 24, 25. Since calpain is a protease, its proapoptotic effect is attributable mainly to its degradative properties.
Protective role of endothelial calpain knockout in ... - Nature
nature.com
Are CAPN1-/- mice resistant to thrombosis in vivo?
More importantly, platelet aggregation, clot retraction, and tyrosine dephosphorylation defects were rescued in the double knockout mice lacking both calpain-1 and PTP1B. Further evaluation of mutant mice by the ferric chloride-induced arterial injury model suggests that the Capn1-/- mice are relatively resistant to thrombosis in vivo.
Double knockouts reveal that protein tyrosine phosphatase
pubmed.ncbi.nlm.nih.gov
Does LPs treat calpastatin overexpression and myeloid-specific CAPN4 knockout?
In addition, mice with calpastatin overexpression (Tg-CAST) and myeloid-specific Capn4 knockout (LYZ/Capn4 −/−) were also treated with LPS, and changes in kidney injury were assessed. BUN concentrations in plasma ( f and h) and caspase-3 activity ( g and i) in kidney tissue were detected.
Protective role of endothelial calpain knockout in ... - Nature
nature.com
Is calpain involved in the crosstalk between inflammation and angiogenesis?
Deletion of Capns1 was associated with elevated levels of IκB and downregulation of β-catenin expression in endothelial cells. These observations delineate a novel mechanistic role for calpain in the crosstalk between inflammation and angiogenesis during skin repair.
Targeted inhibition of endothelial calpain delays wound healing by
nature.com
Do Calpain-1 null platelets accumulate protein tyrosine phosphatase 1B (PTP1B?
Here, we report that calpain-1 null (Capn1-/-) platelets accumulate protein tyrosine phosphatase 1B (PTP1B), which correlates with enhanced tyrosine phosphatase activity and dephosphorylation of multiple substrates.
Double knockouts reveal that protein tyrosine phosphatase
pubmed.ncbi.nlm.nih.gov
Does Calpain-1 inactivation reduce platelet aggregation and clot retraction?
Gene targeting was used to evaluate the physiological function of mouse calpain-1 and establish that its inactivation results in reduced platelet aggregation and clot retraction potentially by causing dephosphorylation of platelet proteins.
Double knockouts reveal that protein tyrosine phosphatase
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Comprehensive behavioral phenotyping of calpastatin-knockout …
2008年9月15日 · It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely …
标记:
Publish Year:2008
Mol Brain. 2008; 1: 7.
Published:2008
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Knockout of calpain‐1 protects against high‐fat diet‐induced liver ...
2020年12月22日 · The present study showed that knockout of calpain‐1 decreased activities of calpain, AST, and ALT, reduced the contents of oxLDL, MDA, TNF‐α, and IL‐6, while …
标记:
Calpain Activity
Publish Year:2021
10.1002/fsn3.2002
Published:2021/01
PubMed
https://pubmed.ncbi.nlm.nih.gov
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout …
2020年11月19日 · Increased podocyte calpain activity-mediated proteolysis of IκBα resulted in increased NF-κB p65-induced expression of growth arrest and DNA-damage-inducible 45 beta …
标记:
Publish Year:2020
Kinase
PubMed
https://pubmed.ncbi.nlm.nih.gov
Impaired cerebellar plasticity and eye-blink conditioning in calpain …
Low frequency stimulation (LFS, 5 Hz, 5 min)-induced LTP at parallel fibers to Purkinje cell synapses was markedly impaired in cerebellar slices from calpain-1 knock-out (KO) mice. …
标记:
Calpain-1
Publish Year:2020
Human Brain
Knockout mouse
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Protective role of endothelial calpain knockout in ... - Nature

Double knockouts reveal that protein tyrosine phosphatase

Protective role of endothelial calpain knockout in ... - Nature

Targeted inhibition of endothelial calpain delays wound healing by

Double knockouts reveal that protein tyrosine phosphatase

Double knockouts reveal that protein tyrosine phosphatase

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